• A high dose of cocaine can cause an individual to overdose.
• This means that a person has used more cocaine than their body can cope with.
• The risk of overdose increases if the strength or purity of the cocaine is not known.
• Injecting cocaine increases the risk of overdose due to large amounts of the drug entering the blood stream and quickly travelling to the brain.

High doses can also result in:

• immediate “rush” feeling
• euphoria
• feelings of invincibility
• a sense of wellbeing
• increased talkativeness or quiet contemplation and rapture
• increased confidence and a feeling of invincibility
• feelings of great physical strength and mental capacity
• increased libido
• feling more awake, reduced need for sleep
• increased performance on simple tasks

C, coke, nose candy, snow, white lady, toot, Charlie, blow, white dust and stardust

Freebase is known as “base”, and crack is referred to as “rock” or “wash”.

• Little is known about the long-term effects of ecstasy.
• There is some evidence that ecstasy can cause damage to some parts of the brain and that regular, heavy use can lead to depression.
• An individual taking ecstasy regularly may find that they are not eating or sleeping enough and neglecting their health.

• jaw clenching
• teeth grinding
• increased blood pressure and heart rate
• nausea
• loss of appetite
• increased body temperature
• sweating
• skin tingles
• dilated pupils
• poor muscle control and unsteadiness
• muscle aches and stiffness
• anxiety
• paranoia
• aggression
• psychosis

• There is evidence that it is possible to become psychologically dependent on ecstasy.
• People who are psychologically dependent on ecstasy may find they feel an urge to use it when they are in specific surroundings or socialising with friends.
• At present, there is no conclusive evidence for physical dependence on ecstasy.
• People who use regularly can develop a tolerance to it which means that they need to take larger amounts to get the same effect.

MDMA primarily inhibits serotonin reuptake and stimulates serotonin release.

MDMA acts as an indirect serotonin (5-HT), norepinephrine (NE), and dopamine (DA) agonist. 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480420/

• The effects of ecstasy start to be felt within 20 minutes to 1 hour after being swallowed, plateau at 2-3 hours after consumption and diminish in intensity over the next 3-4 hours.

• Ecstasy is normally swallowed though it can also be snorted, smoked, injected or inserted into the anus or vagina.
• The effects of ecstasy start to be felt within 20 minutes to 1 hour after being swallowed, plateau at 2-3 hours after consumption and diminish in intensity over the next 3-4 hours.
• Snorting or injecting can result in much quicker onset of effects.
• The “come-up” is the term used to refer to the stage at which the effects begin to be felt. The “peak” describes the effects at their most intense.