Headaches

• Paracetamol (Panadol)
• Massage

Pronounced agitation or insomnia

• Cravings, dysphoria, anhedonia, increased appetite, fatigue, agitation, anxiety, increased sleep, vivid unpleasant dreams and slowing of movement
• Potential Complications
• Hallucinations - Visual or tactile transient hallucinations, paranoia, psychological disturbances, abnormal affect, auditory or visual delusions
• Seizures - Convulsions, sensory disturbances, loss of consciousness
• Agitation - Anger, aggression, irritability, violent outbursts
• Psychosis - Thought disorder and perceptual disturbances

Onset

• Crash phase: within hours of last use
• Withdrawal: 1-4 days after last use

Duration

• 2-4 days
• Acute phase: 7-10 days
• Subacute phase: a further 2-4 weeks

• malnutrition and rapid weight loss due to reduced appetite
• chronic sleeping problems
• reduced immunity and increased susceptibility to infections due to not sleeping or eating properly
• cracked teeth and other dental issues from jaw clenching, teeth grinding, dry mouth and poor hygiene
• high blood pressure and rapid and irregular heartbeat, placing stress on the heart and increasing the risk of heart-related complications such as heart attack and heart failure
• increased strain on the kidneys which may result in kidney failure

• increased heart rate, breathing and body temperature
• decreased appetite
• jaw clenching; teeth grinding
• nausea and vomiting;
• dry mouth
• changes in libido
• nervousness, anxiety, agitation, panic, paranoia
• hallucinations
• repetition of simple acts
• irritability, hostility, aggression
• feelings of increased strength
• itching, picking and scratching
• headaches; dizziness
• difficulty sleeping
• abrupt shifts in thinking and speech
• dilated pupils (enlarged)

• People who use methamphetamines on a regular basis may become dependent on them
• They may also develop a tolerance to methamphetamines, which means they will need to use larger amounts to get the same effect.
• People who become dependent on methamphetamine typically inject or smoke the drug and use it at least twice per week.
• Dependence on methamphetamines can be psychological, physical or both. People who are dependent crave methamphetamine and find it very difficult to stop using it.

In the brain, a primary action of methamphetamine is to elevate the levels of extracellular monoamine neurotransmitters (dopamine, serotonin, norepinephrine) by promoting their release from the nerve endings.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413312/

• Following oral administration, peak methamphetamine concentrations are seen in 2.6-3.6 hours and the mean elimination half-life is 10.1 hours (range 6.4-15 hours).
• The amphetamine metabolite peaks at 12 hours.
• Following intravenous injection, the mean elimination half-life is slightly longer (12.2 hours).
• Overall effects typically last 4-8 hours; residual effects can last up to 12 hours.

As the effects of methamphetamine use begin to wear off, an individual may experience a range of effects.

• Methamphetamine can be swallowed, snorted, smoked or injected.
• Ice is usually smoked or injected.
• Depending on how methamphetamines are taken, the effects may be felt immediately (through injecting or smoking) or within 30 minutes (snorting) and approximately 20-30 minutes if swallowed.